𝔖 Bobbio Scriptorium
✦   LIBER   ✦

MOZ is fused to p300 in an acute monocytic leukemia with t(8;22)

✍ Scribed by Max Chaffanet; Laetitia Gressin; Claude Preudhomme; Valérie Soenen-Cornu; Daniel Birnbaum; Marie-Josèphe Pébusque

Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
336 KB
Volume
28
Category
Article
ISSN
1045-2257

No coin nor oath required. For personal study only.

✦ Synopsis

We report on the fusion of the monocytic leukemia zinc finger protein (MOZ) gene to the adenoviral E1A-associated protein p300 (p300) gene in acute monocytic leukemia M5 associated with a t(8;22)(p11;q13) translocation. We studied two patients with double-color fluorescence in situ hybridization (FISH) using the yeast artificial chromosome 176C9 and the bacterial artificial chromosome clone H59D10 specific to the MOZ and p300 genes, respectively. Both probes were split in the patients' chromosome metaphase cells, and the two derivative chromosomes were each labeled with both probes. We showed by Southern blot the rearrangement of the MOZ gene, and cloned the fusion transcripts in one patient carrying the t(8;22) by reverse transcription-polymerase chain reaction using MOZ- and p300-specific primers. Both fusion transcripts were expressed. This result defines a novel reciprocal translocation involving two acetyltransferases, MOZ and p300, resulting in an abnormal transcriptional co-activator that could play a critical role in leukemogenesis.

📜 SIMILAR VOLUMES

Type I MOZ/CBP (MYST3/CREBBP) is the mos
Type I MOZ/CBP (MYST3/CREBBP) is the most common chimeric transcript in acute myeloid leukemia with t(8;16)(p11;p13) translocation
✍ María Rozman; Mireia Camós; Dolors Colomer; Neus Villamor; Jordi Esteve; Dolors 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 166 KB

## Abstract The t(8;16)(p11;p13) fuses the __MOZ__ (__MYST3__) gene at 8p11 with __CBP__ (__CREBBP__) at 16p13 and is associated with an infrequent but well‐defined type of acute myeloid leukemia (AML) that has unique morphocytochemical findings (monocytoid blast morphology with erythrophagocytosis

PRDX4, a member of the peroxiredoxin fam
PRDX4, a member of the peroxiredoxin family, is fused to AML1 (RUNX1) in an acute myeloid leukemia patient with a t(X;21)(p22;q22)
✍ Yanming Zhang; Neelmini Emmanuel; Ginny Kamboj; Jianjun Chen; Muhammad Shurafa; 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 210 KB 👁 1 views

## Abstract The __AML1__ gene (also known as __RUNX1__) at 21q22 codes for core binding factor (CBF) α, which forms a heterodimer with CBF β that acts as a transcriptional activating factor. CBF is a critical regulator in the generation and differentiation of definitive hematopoietic stem cells and

LAF4, an AF4-related gene, is fused to M
LAF4, an AF4-related gene, is fused to MLL in infant acute lymphoblastic leukemia
✍ Anne R.M. von Bergh; H. Berna Beverloo; Paul Rombout; Elisabeth R. van Wering; M 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 324 KB

## Abstract Infant acute lymphoblastic leukemia (ALL) with __MLL__ gene rearrangements is characterized by a proB phenotype and a poor clinical outcome. We analyzed an infant proB ALL with t(2;11)(p15;p14) and an __MLL__ rearrangement on Southern blot analysis. Rapid amplification of cDNA ends–poly

LPXN, a member of the paxillin superfami
LPXN, a member of the paxillin superfamily, is fused to RUNX1 in an acute myeloid leukemia patient with a t(11;21)(q12;q22) translocation
✍ Hai-Ping Dai; Yong-Quan Xue; Jian-Wei Zhou; Ai-Ping Li; Ya-Fang Wu; Jin-Lan Pan; 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 342 KB 👁 1 views

## Abstract __RUNX1__ (previously __AML1__) is involved in multiple recurrent chromosomal rearrangements in hematological malignances. Recently, we identified a novel fusion between __RUNX1__ and __LPXN__ from an acute myeloid leukemia (AML) patient with t(11;21)(q12;q22). This translocation genera

Human LPP gene is fused to MLL in a seco
Human LPP gene is fused to MLL in a secondary acute leukemia with a t(3;11) (q28;q23)
✍ Laurence Dahéron; Anne Veinstein; Françoise Brizard; Harry Drabkin; Laurence Lac 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 210 KB

## Abstract The mixed lineage leukemia, __MLL__, gene is frequently rearranged in patients with secondary leukemia following treatment with DNA topoisomerase II inhibitors. By FISH and Southern blot analyses we identified a rearrangement in the __MLL__ gene due to a novel t(3;11)(q28;q23) chromosom

A novel gene, FGA7, is fused to RUNX1/AM
A novel gene, FGA7, is fused to RUNX1/AML1 in a t(4;21)(q28;q22) in a patient with T-cell acute lymphoblastic leukemia
✍ Fady M. Mikhail; Lionel Coignet; Nadia Hatem; Zeinab I. Mourad; Hala M. Farawela 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 517 KB

## Abstract __AML1__ is among the most frequent targets of chromosomal rearrangements in human leukemias. We report here the molecular analysis of a t(4;21)(q28;q22) that has disrupted __AML1__ in a patient with de novo T‐cell acute lymphoblastic leukemia. By using 3′‐RACE analysis, we show that th