✦ LIBER ✦

Mouse models of human single gene disorders I: Non-transgenic mice

✍ Scribed by Susan M. Darling; Catherine M. Abbott

Publisher: John Wiley and Sons
Year: 1992
Tongue: English
Weight: 980 KB
Volume: 14
Category: Article
ISSN: 0265-9247
DOI: 10.1002/bies.950140602

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Mouse models of human genetic disorders provide a valuable resource for investigating the pathogenesis of genetic disease and for testing potential therapies. The high degree of resolution of linkage mapping in the mouse allows mutant phenotypes to be mapped precisely which, combined with the accurate definition of areas of homology between the mouse and human genomes, greatly facilitates the identification of mouse models. We describe here mouse models of human single gene disorders dividing them into three categories depending on the information available; phenotypic similarities, comparative mapping and identification of the underlying genetic lesion.

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