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Involvement of autoimmunity against type II collagen in the development of arthritis in mice transgenic for the human T cell leukemia virus type I tax gene

✍ Scribed by Motoko Kotani; Yoh-ichi Tagawa; Yoichiro Iwakura

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
237 KB
Volume
29
Category
Article
ISSN
0014-2980

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✍ Tsvetelina Batsalova; Balik Dzhambazov; Patrick Merky; Alexandra Bäcklund; Johan 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 142 KB 👁 1 views

## Abstract ## Objective To establish a new animal model in DRB1\*0401 (DR4)–transgenic mice in which T cell tolerance to self type II collagen (CII) can be broken and allow for the development of autoimmune arthritis, to investigate the role of posttranslational modifications of the CII^259–273^