Mouse mammary tumor virus and its interaction with the immune system
β Scribed by Susan R. Ross
- Book ID
- 105608322
- Publisher
- Springer-Verlag
- Year
- 1998
- Tongue
- English
- Weight
- 792 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0257-277X
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The mouse mammary tumor virus enters mammary epithelial cells via a plasma membrane protein that binds to a viral envelope glycoprotein, gp52. In intact cells, this gp52 receptor can be phosphorylated by activators of protein kinase A and protein kinase C (PKC), but this modification does not occur
## Abstract IgG binding to purified mouse mammary tumor virus (MuMTV) was quantitated by an enzymeβlinked immunoassay (ELISA) using sera from patients with breast cancer or benign breast disease, or from healthy agematched controls. Significantly greater binding (p<0.01) was found in breastβcancerβ
## Abstract Antibodies to murine mammary tumor virus (MuMTV) were found in sera from male and female mice by means of a radiolabelled intact MuMTV precipitation assay. These antibodies were demonstrated both in strains of mice that have a high incidence of mammary tumors and transmit the highly onc
## Abstract Antibody levels to mouse mammary tumor virus (MuMTV) in sera of C3H/BI, C57BL/6 and AKR mice were assayed by an enzymeβlinked immunosorbent assay (ELISA). It was found that antibody levels to MuMTV were highest in sera of C3H/Bi females which have a high incidence of breast cancer and l