Mouse IL-2-transfected plasmocytoma cells in a therapy of allogeneic tumor-bearing mice
✍ Scribed by Halina Kuśnierczyk; Elżbieta Pajtasz-Piasecka; Czesław Radzikowski
- Book ID
- 117665691
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- English
- Weight
- 124 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0959-8049
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## Abstract A new lymphatic cell antigen of some laboratory mice which also occurs as a tumor‐specific antigen of ascitic mammary tumors of C3H mice was discovered. This antigen is not present in normal cells of C3H/He mice and is therefore capable of eliciting tumor‐specific immune reactions in C3
Tumor cells transfected to express immunostimulatory cytokines, or admixed with similarly modified bystander cells, are able to induce immune responses against unmodified tumor cells in animal models. For treatment of human patients, a vaccine composed of autologous tumor cells and IL-2-secreting al