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Motoneuron survival is promoted by specific exercise in a mouse model of amyotrophic lateral sclerosis

✍ Scribed by Séverine Deforges; Julien Branchu; Olivier Biondi; Clément Grondard; Claude Pariset; Sylvie Lécolle; Philippe Lopes; Pierre-Paul Vidal; Christophe Chanoine; Frédéric Charbonnier


Book ID
110116594
Publisher
Cambridge University Press
Year
2009
Tongue
English
Weight
600 KB
Volume
587
Category
Article
ISSN
0022-3751

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✍ Ilias G. Kirkinezos; Dayami Hernandez; Walter G. Bradley; Carlos T. Moraes 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 138 KB

## Abstract We tested whether a regular exercise regimen was associated with a change in the life span of G93A‐SOD1 transgenic mice, a model of familial ALS. Regular treadmill running for 10 weeks led to a significant increase in the life span of G93A‐SOD1 mice. The effect was stronger in male mice