Mosaicism for a chromosome 8-derived minute marker chromosome in a patient with manifestations of trisomy 8 mosaicism
โ Scribed by Spinner, Nancy B. ;Grace, Kim Rehberg ;Owens, Nancy L. ;Sovinsky, Lorraine ;Pellegrino, Joan E. ;McDonald-McGinn, Donna ;Zackai, Elaine
- Publisher
- John Wiley and Sons
- Year
- 1995
- Tongue
- English
- Weight
- 356 KB
- Volume
- 56
- Category
- Article
- ISSN
- 0148-7299
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## Trisomy 8 Mosaicism in a Patient With Tetraamelia To the Editor: Trisomy 8 is detected in 0.8% of spontaneous abortions . In neoplasias, especially in myeloid leukaemias, trisomy 8 is a frequent somatic aberration . In liveborn infants trisomy 8 almost always is a mosaic condition. The frequen
Constitutional trisomy 8 mosaicism (CT8M) is a relatively rare trisomy in humans with a characteristic phenotype. We report an infant with the characteristic CT8M phenotype in addition to heterotaxia. A number of chromosomal abnormalities have been reported in association with laterality defects but