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Mos is degraded by the 26S proteasome in a ubiquitin-dependent fashion

✍ Scribed by Naruhiro Ishida; Keiji Tanaka; Tomohiro Tamura; Mayumi Nishizawa; Kenji Okazaki; Noriyuki Sagata; Akira Ichihara


Book ID
115927338
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
487 KB
Volume
324
Category
Article
ISSN
0014-5793

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## Abstract **Background:** Recent work has demonstrated the role of cdc kinase subunit 1 (Cks1) in the ubiquitin‐proteasome dependent degradation of CDK inhibitor p27^__Kip1__^ protein as an essential cofactor for SCF^Skp2^ ubiquitin ligase. Although over‐expression of Cks1 protein as well as it o