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Activated c-Abl is degraded by the ubiquitin-dependent proteasome pathway

✍ Scribed by Asier Echarri; Ann Marie Pendergast

Book ID
114318631
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
387 KB
Volume
11
Category
Article
ISSN
0960-9822

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## Abstract **Background:** Recent work has demonstrated the role of cdc kinase subunit 1 (Cks1) in the ubiquitin‐proteasome dependent degradation of CDK inhibitor p27^__Kip1__^ protein as an essential cofactor for SCF^Skp2^ ubiquitin ligase. Although over‐expression of Cks1 protein as well as it o