## Abstract ## BACKGROUND Human nonsyndromic cleft lip and palate, CL(P), is genetically complex, with one contributing gene on chromosome 17q. A potentially homologous gene, __clf1__ on distal chromosome 11, is part of the digenic cause of the 10โ30% CL(P) in the A/WySn mouse strain. Here we repo
Morphology of the orbital region in adults following the cleft lip/palate repair in childhood
โ Scribed by Leslie G. Farkas; William K. Lindsay; Meindert B. Vanderby
- Publisher
- John Wiley and Sons
- Year
- 1972
- Tongue
- English
- Weight
- 652 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0002-9483
No coin nor oath required. For personal study only.
โฆ Synopsis
Four measurements and two qualitative signs related to the orbits of 145 adult Caucasian cleft liplpalate patients operated on in childhood were compared with similar data on 100 normal Caucasian Canadians. The average interorbital distance in male patients with unilateral and bilateral cleft liplpalate was greater than i n controls, while the interorbital distance i n both male and female patients with isolated cleft palate was the same as that in controls. A hypertelorism increased interorbital distance of greater than 2 S.D. above the normal was recorded in 10 cleft patients out of 145, the maximum in male cleft patients being 48 mm and i n female cleft patients 38 mm.
Orbital eye fissure length asymmetry was seen only in the cleft study group while a dislocation of the eye fissure levels i n the frontal plane was found both in patients with clefts and in controls. No direct relationship was found between the extent of the cleft and the incidence of hypertelorism, nor between the site of the cleft and eye fissure asymmetry in unilateral cleft lip/palate patients.
The epicanthic fold was significantly more frequent in cleft lip/palate patients (28/145) than i n controls (lO/lOO). Anti-mongoloid eye fissure type was recorded only in patients with cleft but mongoloid eye fissure was present both in patients with clefts and controls.
๐ SIMILAR VOLUMES
## Abstract ## BACKGROUND Cleft lip with or without cleft palate (CL/P) is one of the most common craniofacial malformations, with a complex and multifactorial etiology. Because of the genetic heterogeneity of facial clefts, the aim of this study was to investigate the contribution of previously r