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Morphological changes of the pancreatic ducts in oletf rats

โœ Scribed by Hamamoto, Naoharu; Ashizawa, Nobuo; Endoh, Hiroshi; Kinoshita, Yoshikazu

Book ID
122523062
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
189 KB
Volume
118
Category
Article
ISSN
0016-5085

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Cyclosporin A (50 mg/kg orally for 7 days) produced severe degranulation and hydropic degeneration of islet B cells in rats. These changes were accompanied by hyperglycaemia and hypoinsulinaemia, while the pancreatic insulin content decreased by 75%.