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Morphological and physiological effects of dopamine D2 receptor knockout on the development of inhibitory circuits in the prefrontal cortex of the mouse

โœ Scribed by B. Roerig; K. Boukamel; A. Moutanni; J.P. Kao; E. Borelli


Book ID
119555497
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
251 KB
Volume
60
Category
Article
ISSN
0920-9964

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Rats received haloperidol (1.3-1.5 mg/kg/day) via their drinking water for 21 weeks. At the end of this period the density of D2 dopamine receptors and their affinity for [3H]-spiperone were measured in the striatum and medial prefrontal cortex. The chronic haloperidol treatment increased the densit