✦ LIBER ✦

Morphologic heterogeneity of acute promyelocytic leukemia: Therapy-related acute promyelocytic leukemia presenting with FAB-M2 morphology

✍ Scribed by S. Sinha; L. Aish; T.H. Oo

Publisher: John Wiley and Sons
Year: 2006
Tongue: English
Weight: 285 KB
Volume: 81
Category: Article
ISSN: 0361-8609
DOI: 10.1002/ajh.20577

No coin nor oath required. For personal study only.

✦ Synopsis

To the Editor: Translocation t(9;22)(q34;q11) is found in 1-2% of newly diagnosed patients with de novo AML. The prognosis of Ph þ AML is very poor with a median survival time of only 7 months. We present two patients with de novo Ph þ AML who received induction chemotherapy and post-remission imatinib therapy.

A 73-year-old man was admitted in November 2003 with fatigue and palpitation. Physical examination showed only pallor. The Hb was 83 g/L, platelets 145 Â 10 9 /L, and WBC 1.4 Â 10 9 /L, 0.12 Â 10 9 /L blast cells. FACS analysis of marrow mononuclear cells showed 22% blast cells positive for HLA-DR, CD34, CD117, CD13, CD33, MPO, and CD38 and partially CD11b. Karyotype analysis of bone V V

📜 SIMILAR VOLUMES

Scrotal ulceration during induction ther

Scrotal ulceration during induction therapy of acute promyelocytic leukemia with ATRA

✍ Keechilat Pavithran; Rajalakshmi Arjun; Raman Aruna; Mathew Thomas 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 69 KB

Morphology of acute promyelocytic leukem

Morphology of acute promyelocytic leukemia with cytogenetic or molecular evidence for the diagnosis: Characterization of additional microgranular variants

✍ Neame, Peter B.; Soamboonsrup, Praniti; Leber, Brian; Carter, Ronald F.; Sunislo 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 472 KB 👁 1 views

Early diagnosis of t(15;17) acute promyelocytic leukemia (APL) is essential because of the associated disseminated intravascular coagulation and the unique response of the disease to all-trans retinoic acid (ATRA) therapy. Early diagnosis depends primarily on morphological recognition. The French-Am

Late relapse of acute promyelocytic leuk

Late relapse of acute promyelocytic leukemia in a patient with no maintenance therapy

✍ Huichun Zhan; Roy Rajasree; Linda Russo; Dilip Patel 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 237 KB

CD34-positive acute promyelocytic leukem

CD34-positive acute promyelocytic leukemia is associated with leukocytosis, microgranular/hypogranular morphology, expression of CD2 and bcr3 isoform

✍ R. Foley; P. Soamboonsrup; R.F. Carter; A. Benger; R. Meyer; I. Walker; Y. Wan; 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 75 KB 👁 1 views

Therapy-related myelodysplastic syndrome

✍ Toshie Ogasawara; Masako Yasuyama; Kiyotaka Kawauchi 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 171 KB 👁 1 views

Exacerbation of coagulopathy with concur

Exacerbation of coagulopathy with concurrent bone marrow necrosis, hepatic and renal dysfunction secondary to all-trans retinoic acid therapy for acute promyelocytic leukemia

✍ Gavin M. Cull; John W. Eikelboom; Paul K. Cannell 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 251 KB 👁 1 views

A 22-year-old female presented with acute promyelocytic leukemia (APL). Treatment with all-trans retinoic acid (ATRA) resulted in a severe exacerbation of the coagulopathy 5 days after its introduction. This was complicated by bone marrow necrosis, parenchymal liver damage and acute tubular necrosis