Therapy-related myelodysplastic syndrome with monosomy 5 after successful treatment of acute myeloid leukemia (M2)

Concurrent translocations of MLL and CBF

Concurrent translocations of MLL and CBFA2 (AML1) genes with new partner breakpoints in a child with secondary myelodysplastic syndrome after treatment of acute lymphoblastic leukemia

✍ Susan Mathew; David Head; Jeffrey E. Rubnitz; Susana C. Raimondi 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 257 KB 👁 1 views

The MLL gene at 11q23 is frequently disrupted by chromosomal translocations in de novo acute myeloid leukemia (AML) and acute lymphoid leukemia (ALL), and in secondary leukemia induced by treatment with inhibitors of topoisomerase II, including the epipodophylotoxins. The CBFA2 gene at 21q22 is also