𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Morphologic changes in blast cells of children with acute lymphoblastic leukemia in relapse

✍ Scribed by Weinblatt, Mark E. ;Ortega, Jorge A. ;Kaplan, Sophie

Publisher
John Wiley and Sons
Year
1983
Tongue
English
Weight
354 KB
Volume
11
Category
Article
ISSN
0098-1532

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✦ Synopsis

Relapse in children with acute lymphoblastic leukemia (ALL) on therapy may be due to development of a resistant clone of blast cells. Seven children who presented initially with the "common"-type, L1 lymphoblast relapsed with a morphologically different and more undifferentiated blast cell. Ail were male, with a median age of 12 years at initial presentation. One child who relapsed while off ther-apy was successfully reinduced and remains in hematologic remission on therapy. The remaining 6 children died within I0 months of relapse. Selection of a resistant clone of lymphoblasts by chemotherapy may be responsible for relapse in children with ALL and should be studied in hopes of controlling the disease.

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