Objective: The analgesic effect of codeine depends on its O-demethylation to morphine via sparteine oxygenase (CYP2D6) in the liver and presumably also via this enzyme in the CNS. We studied the ability of quinidine, which is a potent inhibitor of CYP2D6, to penetrate the blood brain barrier and its
Morphine radioimmunoassay specificity before and after extraction of plasma and cerebrospinal fluid
β Scribed by Patricia Y. Grabinski; Robert F. Kaiko; T. D. Walsh; Kathleen M. Foley; Raymond W. Houde
- Publisher
- John Wiley and Sons
- Year
- 1983
- Tongue
- English
- Weight
- 571 KB
- Volume
- 72
- Category
- Article
- ISSN
- 0022-3549
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