Morphine preference in individual rats after morphine ingestion
✍ Scribed by Lars Rönnbäck
- Publisher
- Springer
- Year
- 1990
- Tongue
- English
- Weight
- 549 KB
- Volume
- 102
- Category
- Article
- ISSN
- 0033-3158
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
C57BL/6J mice will drink large amounts of, and display a highly positive preference for, morphine sulfate when it is dissolved in an aqueous solution of sodium saccharin. In identical test situations DBA/2J mice will drink very little of, and display a strong avoidance toward, the morphine-saccharin
Rats were trained to bar press for intravenous infusions of morphine sulfate during 1-h daily test regions. Rates of morphine self-administration were reduced by bilateral lesions of the substantia nigra and enhanced by lesions of the medial raphe nucleus. Dose-response studies indicated that sensit