Morphine ingestion: Genetic control in mice

✍ Scribed by G. P. Horowitz; G. Whitney; J. C. Smith; F. K. Stephan

• Publisher: Springer
• Year: 1977
• Tongue: English
• Weight: 395 KB
• Volume: 52
• Category: Article
• ISSN: 0033-3158
• DOI: 10.1007/bf00439097

✦ Synopsis

C57BL/6J mice will drink large amounts of, and display a highly positive preference for, morphine sulfate when it is dissolved in an aqueous solution of sodium saccharin. In identical test situations DBA/2J mice will drink very little of, and display a strong avoidance toward, the morphine-saccharin solution. This clear separation between morphine-accepting and morphine-rejecting animals within a single species combined with a quick and simple method of inducing high levels of morphine ingestion could facilitate the discovery of causal factors in opiate addiction.