𝔖 Bobbio Scriptorium
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Morphine and codeine are endogenous components of human cerebrospinal fluid

✍ Scribed by Cardinale, G.J.; Donnerer, J.; Finck, A.D.

Book ID
122660502
Publisher
Elsevier Science
Year
1987
Tongue
English
Weight
107 KB
Volume
20
Category
Article
ISSN
0378-8741

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✍ S. H. Sindrup; K. BrΓΈsen; F. Nielsen; U. Hofmann; G. Mikus; J. Asmussen; S. H. I πŸ“‚ Article πŸ“… 1996 πŸ› Springer 🌐 English βš– 609 KB

Objective: The analgesic effect of codeine depends on its O-demethylation to morphine via sparteine oxygenase (CYP2D6) in the liver and presumably also via this enzyme in the CNS. We studied the ability of quinidine, which is a potent inhibitor of CYP2D6, to penetrate the blood brain barrier and its