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Morphine and codeine are endogenous components of human cerebrospinal fluid

✍ Scribed by George J. Cardinale; Josef Donnerer; A.Donald Finck; Joel D. Kantrowitz; Kazuhiro Oka; Sydney Spector

Book ID
118342420
Publisher
Elsevier Science
Year
1987
Tongue
English
Weight
341 KB
Volume
40
Category
Article
ISSN
0024-3205

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✍ S. H. Sindrup; K. BrΓΈsen; F. Nielsen; U. Hofmann; G. Mikus; J. Asmussen; S. H. I πŸ“‚ Article πŸ“… 1996 πŸ› Springer 🌐 English βš– 609 KB

Objective: The analgesic effect of codeine depends on its O-demethylation to morphine via sparteine oxygenase (CYP2D6) in the liver and presumably also via this enzyme in the CNS. We studied the ability of quinidine, which is a potent inhibitor of CYP2D6, to penetrate the blood brain barrier and its