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Morphine-3-glucuronide has a minor effect on morphine antinociception. Pharmacodynamic modeling

✍ Scribed by Marie Gårdmark; Mats O. Karlsson; Fredrik Jonsson; Margareta Hammarlund-Udenaes


Book ID
109389042
Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
236 KB
Volume
87
Category
Article
ISSN
0022-3549

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✍ Marianne Ekblom; Marie Gårdmark; Margareta Hammarlund-Udenaes 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 555 KB

In this study the pharmacokinetics and pharmacodynamics of morphine-3-glucuronide (M3G) were investigated in rats after i.v. administration as a bolus dose (86.7 pmol kg-I) and as a constant rate infusion (2.9 pmol h-') over 5 days. After the bolus dose, the clearance (Cl) was 12.1 ~0.6mlmin-\*\*kg,