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Delayed antinociceptive effect following morphine-6-glucuronide administration in the rat – pharmacokinetic/pharmacodynamic modelling

✍ Scribed by Marie Gårdmark; Margareta Hammarlund-Udenaes


Book ID
117479886
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
201 KB
Volume
74
Category
Article
ISSN
0304-3959

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✍ Marianne Ekblom; Marie Gårdmark; Margareta Hammarlund-Udenaes 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 555 KB

In this study the pharmacokinetics and pharmacodynamics of morphine-3-glucuronide (M3G) were investigated in rats after i.v. administration as a bolus dose (86.7 pmol kg-I) and as a constant rate infusion (2.9 pmol h-') over 5 days. After the bolus dose, the clearance (Cl) was 12.1 ~0.6mlmin-\*\*kg,