In this study the pharmacokinetics and pharmacodynamics of morphine-3-glucuronide (M3G) were investigated in rats after i.v. administration as a bolus dose (86.7 pmol kg-I) and as a constant rate infusion (2.9 pmol h-') over 5 days. After the bolus dose, the clearance (Cl) was 12.1 ~0.6mlmin-\*\*kg,
Comparison of the discriminative and antinociceptive effects of morphine and its glucuronide metabolites after central or systemic administration in the rat
β Scribed by K. W. Easterling; Stephen G. Holtzman
- Publisher
- Springer
- Year
- 1998
- Tongue
- English
- Weight
- 83 KB
- Volume
- 140
- Category
- Article
- ISSN
- 0033-3158
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