More on purine analog-induced apoptosis in B cell chronic lymphocytic leukemia
✍ Scribed by Morabito, F; Filangeri, M; Sculli, G; Oliva, B
- Book ID
- 110053792
- Publisher
- Nature Publishing Group
- Year
- 1998
- Tongue
- English
- Weight
- 23 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0887-6924
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## Abstract The cytotoxic effects and the induction of programmed cell death (apoptosis) by Fludarabine (FLU), 2‐chlorodeoxyadenosine (2‐CdA), and deoxycoformycin (DCF) with/without α‐interferon (α‐IFN) were evaluated in vitro against freshly isolated B‐chronic lymphocytic leukemia (B‐CLL) cells. C
B-cell chronic lymphocytic leukemia (B-CLL) is characterized by the slow and progressive accumulation of monoclonal apparently mature, CD5 ؉ B lymphocytes. The majority of circulating cells appear to be nondividing, and it has been suggested that a prolonged life span is mainly responsible for the a