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Simvastatin and purine analogs have a synergic effect on apoptosis of chronic lymphocytic leukemia cells

✍ Scribed by Monika Podhorecka; Dorota Halicka; Piotr Klimek; Malgorzata Kowal; Sylwia Chocholska; Anna Dmoszynska

Book ID
105989632
Publisher
Springer
Year
2010
Tongue
English
Weight
207 KB
Volume
89
Category
Article
ISSN
0939-5555

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## Abstract The cytotoxic effects and the induction of programmed cell death (apoptosis) by Fludarabine (FLU), 2‐chlorodeoxyadenosine (2‐CdA), and deoxycoformycin (DCF) with/without α‐interferon (α‐IFN) were evaluated in vitro against freshly isolated B‐chronic lymphocytic leukemia (B‐CLL) cells. C