The object of this study was to evaluate the impact of adjuvant radiation therapy (RT) following radical prostatectomy on urodynamic parameters. Urodynamic evaluation was performed on 10 men who underwent adjuvant RT following radical prostatectomy (study group; 4 studied both before and after) and
Morbidity of radical retropubic prostatectomy following previous prostate resection
โ Scribed by Dr. Jacob Ramon; Georges Rossignol; Pierre Leandri; Jean Romain Gautier; Zev Wajsman
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 523 KB
- Volume
- 55
- Category
- Article
- ISSN
- 0022-4790
No coin nor oath required. For personal study only.
โฆ Synopsis
A total of 153 patients with prior prostate surgery underwent a radical retropubic prostatectomy for carcinoma of the prostate. Ninety-seven patients had undergone transurethral resection of the prostate (TURP), and 56 patients had undergone suprapubic transvesical prostatectomy (SPP). In 115 patients, the diagnosis of malignancy was made at the time of transurethral resection or enucleation. No perioperative deaths occurred and no patient suffered rectal injury or ureteral transection. Operative time and blood loss were similar between the TURP and SPP groups and were not different in a group of patients who had not had prior prostate surgery. Early and late complications occurred in eight patients (5.2%), of whom seven had had previous TURP. Complete urinary control was achieved in 96% (147) of the patients; stress incontinence was present in 4% (6 patients); and no patient was totally incontinent. Postoperative complications and the occurrence of stress incontinence were not related to the time elapsed between the previous prostate surgery and the radical prostatectomy. Sexual function was preserved in 32 (71%) of the 45 patients in whom we performed a nerve-sparing radical prostatectomy . Residual cancer was found in the radical prostatectomy specimen in 77 (67%) of the stage A patients. Twenty-nine (25%) of the stage A and 13 (34%) of the stage B patients had pathological evidence of disease extension beyond the confined prostate. Follow-up was 6 9 2 months, with a mean of 32 months. Four patients died of prostatic cancer, two patients died without cancer, and five have evidence of disease progression; 142 (93%) are alive without evidence of disease. Although radical prostatectomy sometimes is more difficult after previous prostate surgery, operative complication rates, patient morbidity, and the opportunity for surgical cure are not different from those seen in patients with no history of previous prostate operations.
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For the two dysgerminornas in the study by Marx et al. in which overexpression of p53 was detected by LIO-7 and DO-1 in greater than 50% of the tumor cell nuclei, we suggest a further molecular analysis to verify the presence of p.53 mut a t' ion.
Background. This study was performed to evaluate the efficacy of radical prostatectomy for men with clinically localized, poorly differentiated (Gleason score 2 7 ) prostate cancer and to characterize further the prognostic significance of traditional pathologic variables. The effectiveness of adjuv