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Mood and anxiety fluctuation in Parkinson's disease associated with levodopa infusion: Preliminary findings

✍ Scribed by Dr. Robert A. Maricle; John G. Nutt; Julie H. Carter

Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
435 KB
Volume
10
Category
Article
ISSN
0885-3185

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✦ Synopsis

Pilot data on mood and anxiety changes in 15 Parkinson's disease patients with motor fluctuations are described based on ratings every 30 min for 5 h bracketing a 2-h constant-rate levodopa infusion. Robust mood and anxiety effects slightly preceded but temporally paralleled fluctuations in motor tapping scores. Research nurse ratings blind to patient ratings corroborated the changes. The magnitude of changes in mood and anxiety scores did not correlate with the magnitude of changes in tapping scores. The findings of this uncontrolled study suggest mood and anxiety fluctuations may be a common and potentially important component of levodopa-induced fluctuations.

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## Abstract We report our long‐term experience using enteral levodopa infusions in 22 patients with Parkinson's disease and severe motor fluctuations. Amelioration of intractable dyskinesias was the most important factor that determined whether patients chose to continue using the infusion pump sys