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Monoclonal antibody αIR-3 inhibits non-small cell lung cancer growth in vitro and in vivo


Book ID
121901766
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
133 KB
Volume
16
Category
Article
ISSN
0169-5002

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Monoclonal antibody αIR-3 inhibits non-s
✍ Farah Zia; Steve Jacobs; Frederick Kull Jr.; Frank Cuttitta; James L. Mulshine; 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 601 KB

The ability of monoclonal antibody (mAb) alR-3 to interact with non-small cell lung cancer (NSCLC) cells was investigated. MAb alR-3 inhibited specific binding of 1251-IGF-I and 1251-alR-3 to a panel of 8 NSCLC cell lines with high affinity (IC50 = 200 and 50 ng/ml, respectively). 1251-alR-3 bound w