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Monoclonal antibodies to the synthetic adjuvant muramyl dipeptide: Characterization of the specificity

✍ Scribed by G.M. Bahr; Z. Eshhar; R. Ben-Yitzhak; F.Z. Modabber; R. Arnon; M. Sela; L. Chedid


Book ID
119089221
Publisher
Elsevier Science
Year
1983
Tongue
English
Weight
759 KB
Volume
20
Category
Article
ISSN
0161-5890

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## Abstract The mechanism of adjuvant activity of the synthetic glycopeptide N‐acetylmuramyl‐L‐alanyl‐D‐isoglutamine or muramyl dipeptide (MDP) was studied using __in vitro__ plaque‐forming cell (PFC) response to sheep erythrocytes (SRBC). Addition of MDP to DBA/2 mouse spleen cell cultures resulte

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Monoclonal antibodies (MAbs) were prepared to a synthetic peptide (PI : I I94 40 amino acids) in domain I of the carcinoembryonic antigen (CEA) molecule. The majority of the amino acids in peptide P I show a hydrophilic character, and similar sequences are repeated in domains I, II and 111 of this m