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Monoclonal Antibodies to the EGF Receptor Act as Betacellulin Antagonists

โœ Scribed by Helmout Modjtahedi; Christopher Dean

Book ID
115578384
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
266 KB
Volume
221
Category
Article
ISSN
0006-291X

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Anti-EGFR monoclonal antibodies which ac
Anti-EGFR monoclonal antibodies which act as EGF, TGFฮฑ, HB-EGF and BTC antagonists block the binding of epiregulin to EGFR-expressing tumours
โœ Helmout Modjtahedi; Toshi Komurasaki; Hitoshi Toyoda; Christopher Dean ๐Ÿ“‚ Article ๐Ÿ“… 1998 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 294 KB

Epiregulin is the newest member of the epidermal growth factor (EGF) family of ligands that was isolated from conditioned medium of the murine fibroblast-derived tumour cell line NIH3T3/T7. Here, using a panel of anti-EGFR receptor (EGFR) monoclonal antibodies (MAbs) directed against 4 distinct epit