The Binding of HB-EGF to Tumor Cells Is Blocked by mAbs Which Act as EGF and TGFα Antagonists

Anti-EGFR monoclonal antibodies which ac

Anti-EGFR monoclonal antibodies which act as EGF, TGFα, HB-EGF and BTC antagonists block the binding of epiregulin to EGFR-expressing tumours

✍ Helmout Modjtahedi; Toshi Komurasaki; Hitoshi Toyoda; Christopher Dean 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 French ⚖ 294 KB

Epiregulin is the newest member of the epidermal growth factor (EGF) family of ligands that was isolated from conditioned medium of the murine fibroblast-derived tumour cell line NIH3T3/T7. Here, using a panel of anti-EGFR receptor (EGFR) monoclonal antibodies (MAbs) directed against 4 distinct epit