Monoclonal Antibodies in Transplantation

✍ Scribed by Lucienne Chatenoud M.D., D.Sc. (auth.)

• Publisher: Springer-Verlag Berlin Heidelberg
• Year: 1995
• Tongue: English
• Leaves: 198
• Series: Medical Intelligence Unit
• Edition: 1
• Category: Library

✦ Synopsis

Experimental and clinical evidence presented in this book illustrates that antibodies expressing different specificities can be very effective in preventing or reversing established transplant rejection. Moreover, the data leads us to hope that the use of these new therapeutic agents may allow the induction of specific tolerance to transplant alloantigens which is the only means to avoid the major risks of sustained immunosuppression, namely an increased susceptibility to infection and tumor development. In this volume the editors combine contributions dealing with very practical aspects of the clinical use of monoclonal antibodies with a more general discussion on the developments one may foresee in the near future.

✦ Table of Contents

Front Matter....Pages N2-xi
Clinical Uses of Polyclonal and Monoclonal Antilymphoid Sera....Pages 1-19
The Experimental and Clinical Use in Transplantation of Monoclonal Antibodies to CD4 and Other Adhesion Molecules....Pages 21-52
The Clinical and Experimental Use of Monoclonal Antibodies to the IL-2 Receptor....Pages 53-98
The Use of OKT3 in Clinical Transplantation....Pages 99-135
Monoclonal Antibodies to Adhesion Molecules in Bone Marrow and Organ Transplantation....Pages 137-153
Future Goals for Therapeutic Monoclonal Antibodies....Pages 155-182
Back Matter....Pages 183-190

✦ Subjects

Immunology