Monoamine oxidase inhibiting activity of a series of (±)-4-methoxy-β-hydroxyphenethylamines

✍ Scribed by Gary G. Ferguson; William J. Keller

• Publisher: John Wiley and Sons
• Year: 1975
• Tongue: English
• Weight: 214 KB
• Volume: 64
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600640844

✦ Synopsis

The synthesis and selected pharmacological testing of (f)-4-methoxy-~-hydroxyphenethylamine [1-(4-methoxyphenyl)-2-aminoethanol] and its N-methylated derivatives are presented.

Members of this series were found to exert partial prevention of reserpine-induced hypothermia in mice and to inhibit monoamine oxidase in Warburg studies. Activity was essentially dose dependent. The secondary amine was the most active member of the series. The tertiary amine was least active, and the primary amine exhibited intermediate activity.

Keyphrases 0 (f)-4-Methoxy-&hydroxyphenethylamine and Nmethyl derivatives-synthesis, screened for monoamine oxidase inhibition 0 Monoamine oxidase inhibition-synthesis and screening of (f)-4-methoxy-&hydroxyphenethylamine and N-methyl derivatives 0 0-Hydroxyphenethylamines, 4-methoxy and Nmethyl derivatives-synthesis, screened for monoamine oxidase inhibition Aldrich Chemical Co. K and K Laboratories. Telethermometer model 43TA with probes, model 402, Yellow Springs Instrument Co.