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Monoacylation of ribonuclease A enables its transport across an in vitro model of the blood–brain barrier

✍ Scribed by Joël Chopineau; Stéphane Robert; Laurence Fénart; Roméo Cecchelli; Bernard Lagoutte; Stéphanie Paitier; Marie-Pierre Dehouck; Dominique Domurado


Book ID
114163619
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
210 KB
Volume
56
Category
Article
ISSN
0168-3659

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Transport of carnitine in RBE4 cells - a
✍ Joanna E. Mroczkowska; Françoise S. Roux; Hans-Joachim Galla; Maciej J. Nalecz; 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 514 KB

Accumulation of carnitine was studied in immortalized rat brain capillary endothelial cells R B E ~, as an in vitro model of blood-brain barrier. Both uptake and efflux phenomena were found independent on "a+] gradient. A quick acylation of carnitine in RBE4 cells was observed, especially leading to