Mono-6-(O-2,4,6-triisopropylbenzenesulfonyl)-γ-cyclodextrin, a novel intermediate for the synthesis of mono-functionalised γ-cyclodextrins

✍ Scribed by Ronald Palin; Simon J.A Grove; Alan B Prosser; Ming-Qiang Zhang

• Publisher: Elsevier Science
• Year: 2001
• Tongue: French
• Weight: 131 KB
• Volume: 42
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(01)01934-7

✦ Synopsis

A reaction between g-cyclodextrin (g-CD) and 2,4,6-triisopropylbenzenesulfonyl chloride in pyridine gave mono-6-(O-2,4,6-triisopropylbenzenesulfonyl)-g-cyclodextrin in good yield ( 69%) and high purity (>98%). In contrast to other sulfonylations of g-CD, this reaction did not give di-or tri-substituted side products and is thus useful for preparing pure mono-substituted g-CD derivatives.