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Novel applications of convertible isonitriles for the synthesis of mono and bicyclic γ-lactams via a UDC strategy

✍ Scribed by Christopher Hulme; Liang Ma; Marie-Pierre Cherrier; Joseph J Romano; George Morton; Celine Duquenne; Joseph Salvino; Richard Labaudiniere


Publisher
Elsevier Science
Year
2000
Tongue
French
Weight
178 KB
Volume
41
Category
Article
ISSN
0040-4039

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A successful one-pot reduction of g-ketoesters, d-ketoesters and lactones to the corresponding 1,4-and 1,5-diols followed by a lipase catalyzed kinetic resolution coupled with hydrolysis to afford optically active diols is described. The synthetic utility of this one-pot method was illustrated by th