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Molecular Weights of CTLA-4 and CD80 by Sedimentation Equilibrium Ultracentrifugation

✍ Scribed by Robert Fairman; William Fenderson; Mark E. Hail; Youling Wu; Shyh-Yu Shaw


Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
134 KB
Volume
270
Category
Article
ISSN
0003-2697

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CD28 and CTLA-4 are opposing regulators of T cell activation, triggered by the two ligands CD80 and CD86. How these ligands promote either T cell activation via CD28 or inhibition via CTLA-4 is not understood. Using CD80 and CD86 molecules expressed on transfected cells, we have identified a major d