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Molecular targets of apigenin in colorectal cancer cells: Involvement of p21, NAG-1 and p53

✍ Scribed by Yi Zhong; Chutwadee Krisanapun; Seong-Ho Lee; Thararat Nualsanit; Carl Sams; Penchom Peungvicha; Seung Joon Baek

Book ID
116430472
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
855 KB
Volume
46
Category
Article
ISSN
0959-8049

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## Abstract Genistein is an isoflavenoid found in soy that has anti‐tumorigenic activities. Treatment of colorectal carcinoma HCT‐116 cells with 50 ΞΌM genistein results in a 50% reduction in cell proliferation and a 6‐fold increase in apoptosis. Genistein induces nonsteroidal anti‐inflammatory drug