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Molecular targeting with recombinant cytotoxins of interleukin-13 receptor α2-expressing glioma

✍ Scribed by Akiva Mintz; Denise M. Gibo; A. B. Madhankumar; Waldemar Debinski


Book ID
110632446
Publisher
Springer US
Year
2003
Tongue
English
Weight
831 KB
Volume
64
Category
Article
ISSN
0167-594X

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## Abstract DAB~486~IL‐2 is a genetically engineered fusion protein consisting of a portion of diphtheria toxin fused to human IL‐2. It is specifically cytotoxic for tumor cells which bear high‐affinity IL‐2 receptors (IL‐2R). DAB~389~IL‐2 is a similarly constructed hybrid protein which is smaller