## Abstract Numerous reports suggest that interleukin‐6 (IL‐6) promotes survival and proliferation of tumor cells through the phosphorylation of a cell‐signaling protein, signal‐transducer‐and‐activator‐of‐transcription‐3 (STAT3). Constitutive activation of STAT3 in head and neck squamous cell carc
✦ LIBER ✦
Apoptotic pathways of cell death induced by an interleukin-13 receptor-targeted recombinant cytotoxin in head and neck cancer cells
✍ Scribed by Mariko Kawakami, Koji Kawakami, Raj K. Puri
- Publisher
- Springer-Verlag
- Year
- 2002
- Tongue
- English
- Weight
- 361 KB
- Volume
- 50
- Category
- Article
- ISSN
- 0340-7004
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## Abstract Overexpression of the interleukin‐2 receptor (IL‐2R) α chain in tumor cells is associated with tumor progression and a poor patient prognosis. IL‐2Rα is responsible for the high affinity binding of the receptor to IL‐2, leading to activation of several proliferative and anti‐apoptotic i