Molecular Target Approaches in Head and Neck Cancer: Epidermal Growth Factor Receptor and Beyond
β Scribed by Paul M. Harari; Deric L. Wheeler; Jennifer R. Grandis
- Book ID
- 113900737
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 367 KB
- Volume
- 19
- Category
- Article
- ISSN
- 1532-9461
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## Abstract The epidermal growth factor receptor (EGFR) has been shown to be a promising therapeutic target in head and neck cancer. Cetuximab, a monoclonal antibody against EGFR, has been approved in the United States for use with radiotherapy for head and neck squamous cell carcinoma. However, th
## Background: Over-expression of human epidermal growth factor receptor (egfr) is associated with a variety of human malignancies, including head and neck cancer. it has also been studied for its effect on cancer cell responses to chemotherapy. to accurately measure changes in egfr expression that
We studied epidermal growth factor receptor (EGFR) gene amplification and expression in 11 early passage human head and neck carcinoma cell lines. Three cell lines demonstrated EGFR gene amplification and 10 lines showed an increase in EGFR mRNA when compared with normal keratinocytes, placenta, and