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Molecular study and epitope mapping of the human antibody response against HCV/E2 glycoprotein by generation of monoclonal recombinant Fabs

โœ Scribed by Campli, Crsitiana Di; Burioni, Roberto; Bugli, Francesca; Desogus, Alessandra; Vannini, Alessandro; Mancini, Nicasio; Canducci, Filippo; Manzin, Alessandro; Gasbarrini, Giovanni B.; Fadda, Giovanni; Gasbarrini, Antonio


Book ID
121917726
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
191 KB
Volume
118
Category
Article
ISSN
0016-5085

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Demonstration of antibodies inhibiting key viral functions is the basis for the design of an effective vaccine. Dissection of the human antibody response by repertoire cloning may be a powerful means to address this issue. In this study, a panel of human monoclonal recombinant Fab fragments specific