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Molecular dissection of the human humoral response against HCV E2 glycoprotein by cloning of the antibody repertoire in phage display combinatorial vectors

โœ Scribed by R. Burioni; F. Bugli; N. Mancini; A. Greco; C. Di Campli; F. Canducci; E. Petrelli; A. Gasbarrini; M. Clementi

Book ID
119527281
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
264 KB
Volume
34
Category
Article
ISSN
0168-8278

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Dissection of human humoral immune respo
Dissection of human humoral immune response against hepatitis C virus E2 glycoprotein by repertoire cloning and generation of recombinant fab fragments
โœ Roberto Burioni; Paola Plaisant; Aldo Manzin; Domenico Rosa; Valeria Delli Carri ๐Ÿ“‚ Article ๐Ÿ“… 1998 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 166 KB

Demonstration of antibodies inhibiting key viral functions is the basis for the design of an effective vaccine. Dissection of the human antibody response by repertoire cloning may be a powerful means to address this issue. In this study, a panel of human monoclonal recombinant Fab fragments specific