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Molecular steps in sGC activation

✍ Scribed by Elizabeth M Boon; Stephen PL Cary; Shirley H Huang; Jonathan A Winger; Emily R Derbyshire; Mark S Price; William K Erbil; Michael A Marletta

Publisher
BioMed Central
Year
2007
Tongue
English
Weight
729 KB
Volume
7
Category
Article
ISSN
1471-2210

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sGC activation in pulmonary hypertension
sGC activation in pulmonary hypertension
✍ Ardeschir Ghofrani; Friedrich Grimminger πŸ“‚ Article πŸ“… 2005 πŸ› BioMed Central 🌐 English βš– 185 KB

Impairments of the NO-sGC-cGMP pathway provoke acute and chronic vascular injury, including endothelial dysfunction, vasoconstriction and vascular remodeling in the pulmonary circulation. We evaluated the effects of the novel sGC activator Bay 41-2272 in three different models of acute and chronic p