Antifibrotic effects of an sGC activator in rat models of liver fibrosis
✍ Scribed by Claudia Hirth-Dietrich; Cristina Alonso-Alija; Michael Härter; Michael G Hahn; Yvonne Keim; Frank Wunder; Andreas Knorr; Johannes-Peter Stasch
- Publisher
- BioMed Central
- Year
- 2005
- Tongue
- English
- Weight
- 188 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1471-2210
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
Liver fibrosis is characterized by increased synthesis, and decreased degradation, of extracellular matrix (ECM) within the injured tissue. Decreased ECM degradation results, in part, from increased expression of tissue inhibitor of metalloproteinase-1 (TIMP-1), which blocks matrix metalloproteinase
Silymarin (SIL), a standardized plant extract containing about 60% of the polyphenol silibinin, is used as a hepatoprotective agent. In order to explore the effect of SIL on liver cell regeneration in a model of progressive biliary liver fibrosis this substance was applied to adult Wistar rats that
## Abstract Although different treatment modalities have been implemented for pulmonary fibrosis, the results have not been promising and these conditions have been considered untreatable and irreversible. Thus, a plethora of new drugs has been tried for the control of this condition in recent year