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Molecular single-cell analysis of Hodgkin and Reed-Sternberg cells

✍ Scribed by Ralf Küppers; Martin-Leo Hansmann; Volker Diehl; Klaus Rajewsky

Book ID
116175435
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
691 KB
Volume
1
Category
Article
ISSN
1357-4310

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## Abstract Hodgkin's and Reed/Sternberg (HRS) cells, the tumour cells in classical Hodgkin's lymphoma (HL), represent transformed B cells in nearly all cases. The detection of destructive somatic mutations in the rearranged immunoglobulin (Ig) genes of HRS cells in classical HL indicated that they