Molecular Simulations of Mutually Exclusive Folding in a Two-Domain Protein Switch
β Scribed by Mills, Brandon M.; Chong, Lillian T.
- Book ID
- 119208100
- Publisher
- Biophysical Society
- Year
- 2011
- Tongue
- English
- Weight
- 967 KB
- Volume
- 100
- Category
- Article
- ISSN
- 0006-3495
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π SIMILAR VOLUMES
Model-free methods are introduced to determine quantities pertaining to protein domain motions from normal mode analyses and molecular dynamics simulations. For the normal mode analysis, the methods are based on the assumption that in low frequency modes, domain motions can be well approximated by m
## Abstract The influences of temperature, friction, and random forces on the folding of protein A have been analyzed. A series of allβatom molecular dynamics folding simulations with the Amber ff99 potential and Generalized Born solvation, starting from the fully extended chain, were carried out f