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Allosteric Switching by Mutually Exclusive Folding of Protein Domains

✍ Scribed by Tracy L. Radley; Anna I. Markowska; Blaine T. Bettinger; Jeung-Hoi Ha; Stewart N. Loh

Book ID
117143473
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
373 KB
Volume
332
Category
Article
ISSN
0022-2836

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## Abstract Alternate frame folding (AFF) is a mechanism by which conformational change can be engineered into a protein. The protein structure switches from the wild‐type fold (__N__) to a circularly‐permuted fold (__N__β€²), or vice versa, in response to a signaling event such as ligand binding. De