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Molecular Signature of CD8+ T Cell Exhaustion during Chronic Viral Infection

✍ Scribed by E. John Wherry; Sang-Jun Ha; Susan M. Kaech; W. Nicholas Haining; Surojit Sarkar; Vandana Kalia; Shruti Subramaniam; Joseph N. Blattman; Daniel L. Barber; Rafi Ahmed

Book ID: 116570806
Publisher: Elsevier Science
Year: 2007
Tongue: English
Weight: 32 KB
Volume: 27
Category: Article
ISSN: 1074-7613
DOI: 10.1016/j.immuni.2007.11.006

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## Abstract The hallmark of chronic viral infections is a progressive exhaustion of antigen‐specific CD8^+^ T cells that leads to persisting viral replication. It is generally believed that exhaustion is a consequence of the accumulation of multiple inhibitory receptors on CD8^+^ T cells that makes