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Molecular Requirements for the Action of 2-APB on STIM1-Orai1 Coupling

✍ Scribed by Wang, Youjun; Deng, Xiaoxiang; Mancarella, Salvatore; Hendron, Eunan; Wang, Xizhuo; Balla, Tamas; Muallem, Shmuel; Yuan, Joseph; Gill, Donald L.


Book ID
122167281
Publisher
Biophysical Society
Year
2013
Tongue
English
Weight
40 KB
Volume
104
Category
Article
ISSN
0006-3495

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Mutational analysis of molecular require
✍ Roberta Siegwart; Karin KrΓ€henbΓΌhl; Sachar Lambert; Uwe Rudolph πŸ“‚ Article πŸ“… 2003 πŸ› BioMed Central 🌐 English βš– 623 KB

Background: Amino acids in the Ξ² subunit contribute to the action of general anaesthetics on GABA A receptors. We have now characterized the phenotypic effect of two Ξ² subunit mutations in the most abundant GABA A receptor subtype, Ξ±1Ξ²2Ξ³2. ## Results: The Ξ²2(N265M) mutation in M2 decreased the mo